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MS instruments at the IMSC

The list of MS equipment below is organized by instrument type and for each instrument information on the most commonly associated HPLC systems and ion sources is shown. HPLCs are often interchangeable, ion sources less commonly so. High-resolution MS systems and ion traps are most useful for identification and characterization of compounds, while triple quadrupole MS systems are mostly used for targeted quantification. In combination with LC separation both types are suitable for analysis of complex samples. Different ionization methods are used for specific compound classes but the bulk of the analyses are performed with electrospray ionization (ESI). NanoLC and nanoESI are used for small sample amounts, primarily for proteomics applications. MALDI-TOF is suitable for fast analysis of single compounds and simple mixtures, particularly of large molecules (intact biomacromolecules and polymers).

High resolution MS

MS instrument MS Manufacturer MS type Ionization source LC instrument LC Manufacturer
Orbitrap Exploris 480 Thermo quadrupole-orbitrap ESI, nanoESI Ultimate 3000 nanoHPLC Thermo
Orbitrap Exploris 480 Thermo quadrupole-orbitrap ESI, nanoESI Evosep One nanoHPLC Evosep
Q Exactive Plus Thermo quadrupole-orbitrap ESI, nanoESI Ultimate 3000 nanoHPLC Thermo
Orbitrap Velos Pro Thermo linear trap-orbitrap ESI, nanoESI Ultimate 3000 nanoHPLC Thermo
Prominence UFLC Shimadzu
MaXis plus Bruker quadrupole-time of flight ESI, nanoESI Waters Acquity UPLC Waters
TripleTOF 6600+ Sciex quadrupole-time of flight ESI, nanoESI Exsigent NanoLC 400 Sciex

Triple quadrupole MS

MS instrument MS Manufacturer Ionization source LC instrument LC Manufacturer
API 4000 Sciex ESI, nanoESI, APCI, Prominence UFLC Shimadzu
API 4000 Sciex ESI, nanoESI, APCI, Prominence UFLC Shimadzu
Xevo-TQ-S Waters ESI, IonKey chip-based ESI nanoAcquity Waters
TSQ Altis Thermo ESI, nanoESI Ultimate 3000 nanoHPLC Thermo
TSQ Vantage Thermo ESI, nanoESI Ultimate 3000 nanoHPLC Thermo
TSQ Vantage Thermo ESI, nanoESI, APCI Ultimate 3000 nanoHPLC Thermo
TSQ Quantum Ultra Thermo ESI Shimadzu UPLC Thermo
TSQ Quantum Ultra Thermo ESI Shimadzu UPLC Thermo
TSQ Quantum Discovery MAX Thermo ESI 1100/1200 series HPLC Agilent

MALDI-TOF MS

MS instrument MS Manufacturer MS type
UltrafleXtreme Bruker MALDI-TOF/TOF


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