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MS instruments at the IMSC

The list of MS equipment below is organized by instrument type and for each instrument information on the most commonly associated HPLC systems and ion sources is shown. HPLCs are often interchangeable, ion sources less commonly so. High-resolution MS systems and ion traps are most useful for identification and characterization of compounds, while triple quadrupole MS systems are mostly used for targeted quantification. In combination with LC separation both types are suitable for analysis of complex samples. Different ionization methods are used for specific compound classes but the bulk of the analyses are performed with electrospray ionization (ESI). NanoLC and nanoESI are used for small sample amounts, primarily for proteomics applications. MALDI-TOF is suitable for fast analysis of single compounds and simple mixtures, particularly of large molecules (intact biomacromolecules and polymers).

High resolution MS

MS instrument MS Manufacturer MS type Ionization source LC instrument LC Manufacturer
LTQ-Orbitrap XL Thermo linear trap-orbitrap ESI, nanoESI Ultimate 3000 nanoHPLC Dionex
Prominence UFLC Shimadzu
Synapt G2-Si Waters quadrupole-time of flight ESI Acquity UPLC Waters
MaXis plus Bruker quadrupole-time of flight ESI, nanoESI Ultimate 3000 nanoHPLC Dionex/Thermo
Q Exactive Plus Thermo quadrupole-orbitrap ESI, nanoESI Ultimate 3000 nanoHPLC Dionex/Thermo

Triple quadrupole MS

MS instrument MS Manufacturer Ionization source LC instrument LC Manufacturer
Xevo-TQ-S Waters ESI, IonKey chip-based ESI Acquity UPLC Waters
nanoAcquity Waters
TSQ Vantage Thermo ESI, nanoESI Ultimate 3000 nanoHPLC Dionex/Thermo
TSQ Vantage Thermo ESI, nanoESI, APCI Accela UPLC Thermo
Ultimate 3000 nanoHPLC Dionex/Thermo
TSQ Quantum AM Thermo ESI, APCI, APPI Surveyor HPLC Thermo
LC Packings Ultimate nanoLC Dionex
API 3000 PE Sciex ESI, nanoESI, APCI, APPI Prominence UFLC Shimadzu
API 365, upgraded EP10+ PE Sciex, Ionics ESI Ultimate 3000 nanoHPLC Dionex
API 365, upgraded EP10+ PE Sciex, Ionics ESI LC Packings Ultimate nanoLC Dionex
6410 Agilent ESI, nanoChipCubeESI 1200 series nanoHPLC Agilent

Ion trap MS

MS instrument MS Manufacturer Ionization source LC instrument LC Manufacturer
HCTultra ETDII Bruker nanoChipCubeESI 1100/1200 series HPLC Agilent

MALDI-TOF MS

MS instrument MS Manufacturer MS type
Voyager DE-Pro Applied Biosystems MALDI-TOF
UltrafleXtreme Bruker MALDI-TOF/TOF



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